Institute of Medicine Committee Chaired By Berman Institute Deputy Director, Jeff Kahn, Calls For an End to Most Research on Chimpanzees

In a report released today on the use of chimpanzees in biomedical and behavioral research, the Institute of Medicine (IOM) of the National Academies of Science called for a dramatic shift away from federally-funded experimentation on humanity’s closest relative in the animal kingdom.

The report, titled “The Use of Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity,” concludes that scientific advances now provide effective alternatives to the use of chimpanzees, and that “most current use of chimpanzees for biomedical research is unnecessary.” The IOM conducted a study of the use of the animals in research in collaboration with the National Research Council and at the request of the National Institutes of Health (NIH), which has financed the majority of federally supported experimentation with chimps.”

We were charged with determining if chimpanzees are necessary for the success of current and future research, and we set a high bar for determining that necessity with uniform criteria,” said the IOM committee chair Jeffrey Kahn, Ph.D., M.P.H., Deputy Director of the Johns Hopkins Berman Institute of Bioethics. “In almost all cases, we found that research on chimpanzees was not necessary.”

The committee stopped short of recommending an end to all research on chimpanzees, finding sufficient cause for continued work in three specific areas:

1. Comparative studies of chimpanzee and human brain function

2. Studies, in the short term, on monoclonal antibodies which precisely target viruses and bacteria, until recombinant technologies can fully replace the chimpanzee

3. Development of a prophylactic Hepatitis C vaccine, an issue which evenly split the committee over whether a challenge study is necessary in such vaccine development since such research could not ethically be performed in humans. The Hepatitis C virus only infects humans and chimpanzees.

The United States and Gabon are the only the only countries known to allow invasive research on chimpanzees. Though the European Union has an exception for using chimpanzees in the event of ‘a serious pandemic,’ no EU nation keeps chimpanzees in captivity or conducts research on them.

“The IOM’s recommendations bring us closer to the ethically correct policy of not allowing any invasive research on chimpanzees,” said Ruth Faden, Ph.D., Director of the Johns Hopkins Berman Institute of Bioethics. “With these new criteria, the government can begin phasing out its support of this research,” Faden added.

Kahn, the only bioethicist on the Committee, noted the challenge of chimpanzee research. “Chimpanzees are attractive research subjects for the same reason that conducting research on them is ethically troubling,” he said. “They are humans’ closest genetic relative, with immune systems that are nearly indistinguishable from ours,” Kahn added. “However, this close relationship also creates a high moral cost, which the Committee agrees must be factored into the assessment of the necessity of any research involving chimpanzees.”

Links:

Guiding Limited Use of Chimpanzees in Research, Science (Policy Forum)

IOM Report Recommends Stringent Limits on Use of Chimpanzees in Biomedical and Behavioral Research, IOM Press Release

Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity, IOM Report

Advisory panel calls for end to most experiments on chimpanzees, Baltimore Sun

Most Research on Chimps Is Unnecessary, U.S. Panel Says, New York Times

Committee Recommends NIH Continue Chimpanzee Research, With New Limits, Science (News & Analysis)

Chimp research rarely warranted: US expert panel, Reuters

NIH temporarily bans new chimpanzee research, Washington Post

Gov’t to adopt strict new limits on chimp research, AP

Breaking: Panel Says To Cease Most Chimp Research, Wired Science

Bioemedical Research Using Chimps Should Be Curtailed, NPR Shots Blog

Chimpanzee research rarely needed: US experts, AFP

Chimpanzee Use in Research Should Be Restricted, Panel Says, Bloomberg

Panel: Limit medical experiments on chimps, USA Today

Last days of chimp research? Report calls for strict limits, MSNBC

US bioethics panel urges stronger protections for human subjects, Nature News

A Response to the IOM Report on the Use of Chimpanzees in Biomedical and Behavioral Research
, Kennedy Institute of Ethics

Restricted use of chimps in government research recommended
, The Chart