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Stem-cell Research
Programs and Recent Projects & Activities
Embryonic Stem-cell Oversight Committee (ESCRO) – All research at the JHU School of Medicine using human embryonic stem cells and/or somatic cell nuclear transfer must undergo review and approval by the ESCRO committee and is subject to ESCRO committee oversight. Jeremy Sugarman co-chairs the ESCRO committee at Johns Hopkins. Andrew Siegel and Debra Mathews serve as members.
SCOPE (Stem Cell Policy and Ethics)Program – The SCOPE program (formerly known as the Program in Cell Engineering, Ethics, and Public Policy, or PCEEPP) mission is to facilitate the ability of the public to benefit from advances in cell engineering in morally responsible ways; Anticipate moral and policy challenges in stem cell science and cell engineering; and Provide opportunity for careful and interdisciplinary analysis of these challenges that will be of assistance to both policymakers and the public. More The Hinxton Group - In early 2004, members of the Stem Cell Policy and Ethics Program (SCOPE) at the The Johns Hopkins Berman Institute of Bioethics began developing a new project, aspiring to bring together an esteemed, international and interdisciplinary group to explore the ethical and policy challenges of transnational scientific collaboration raised by variations in national regulations governing embryo research and stem cell science. While this project was originally planned as a single meeting in Hinxton, UK, the delegates, calling themselves the ‘Hinxton Group’, decided that there were additional challenges they would be able and willing to address, and that this group should not dissolve. Coordinated by a US/UK steering committee, the Hinxton Group is an informal collection of individuals interested in ethical and well-regulated science. The group has now completed a second meeting and future Hinxton Group meetings are being planned. www.hinxtongroup.org
Cell-based Interventions for Neurologic Conditions - This project brought together an interdisciplinary working group of experts in the scientific, legal, and ethical issues involved in cell-based interventions for neurological conditions. The group met twice in a 2-year period in order to identify and deliberate on the ethical and scientific issues involved in the transition from basic science research to clinical trials. The project was supported through a grant from the Greenwall Foundation, and the BI-affiliated group members included Debra Mathews, Jeremy Sugarman, Hilary Bok, Alan Regenberg, Andrew Siegel, and Ruth Faden.
Publications
Regenberg A, Mathews DJH, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ. The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. J Cerebral Blood Flow & Metabolism 2009; 20:1-9.
Mathews DJ, Sugarman J, Bok H, Blass DM, Coyle JT, Duggan P, Finkel J, Greely HT, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Regenberg A, Siegel AW, Smith K, Solter D, Song H, Vescovi A, Young W, Gearhart JD, Faden R. Cell-based interventions for neurologic conditions: Ethical challenges for early human trials. Neurology 2008; 71: 1-6.
More
Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermeren G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ. New ISSCR Guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell 2008;3:607-609.
McCullough J, Kahn J, Adamson J, Anderlini P, Benjamin R, Confer D, Eapen M, Hirsch B, Kuter D,Lazarus E, Pamphilon D, Stronek D, Sugarman J, Wilson R. Hematopoietic growth factors – use in normal blood and stem cell donors: clinical and ethical issues: summary of a conference. Transfusion 2008; 48:2008-25.
Sugarman J, Siegel AW. When embryonic stem cell lines fail to meet consent standards. Science 2008; 322: 379.
Sugarman J, Siegel A. How to determine whether existing human embryonic stem cell lines can be used ethically. Cell Stem Cell 2008; 3: 238-9.
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